Younger and older people gained greater protection if they had their jabs in the middle of the day.
The time of day at which a person receives a COVID-19 vaccine might influence how well it protects them from the disease1.
To evaluate the impact of timing on vaccine effectiveness, Guy Hazan at Washington University in Saint Louis, Missouri, and colleagues evaluated a data set of more than 1.5 million people who had received at least one COVID-19 shot.
People who had been vaccinated in the middle of the day — between late morning and early afternoon — had a lower risk of SARS-CoV-2 infection than did those who had received their jab in the evening, according to the analysis. The benefits of being vaccinated during the day were greater for people younger than 20 and older than 50.
The phenomenon might be associated with the body’s circadian rhythm, daily oscillations driven by the day–night cycle. But the exact mechanism responsible for the link between vaccination time and effectiveness is still unclear.
The findings might inform future immunization strategies that would prioritize vaccinating younger and older people between late morning and early afternoon, the authors suggest.
Or it has everything to do with the storage practice at the vaccination site and the alertness of the vaccination staff. Did they not say that each vial has to be shaken 10 times up and down before withdrawing with the syringe?
This MUST only be done if the vials are fresh and have been properly stored since then right up until the needle sucks it up and jabs some poor “unsuspecting” (read “utterly unaware of objective reality”) SUCKER and another one “potentially”😏 bites the dust. The vials must have been rotated and revolved ten times COUNTERCLOCKWISE(this is VITAL!) and THEN clockwise 🔁. Only FRESH NEEDLES and SYRINGES must be used.
Nature article is paywalled. Does anyone know if it’s the same study I found (link below) dated 7 December 2021?
I starting to wonder if these articles were originally published by The Onion. 🤔
https://news.harvard.edu/gazette/story/2021/12/time-of-day-matters-when-getting-covid-vaccine/#:~:text=Our%20internal%2024%2Dhour%20circadian,the%20afternoon%20versus%20the%20morning.
I noticed the same. I wondered if perhaps this study is a follow up to the 2021 one. I’m not prepared to pay to find out $
Here's the article:
RESEARCH HIGHLIGHT
03 May 2023
Timing matters for COVID vaccine effectiveness
Younger and older people gained greater protection if they had their jabs in the middle of the day.
The time of day at which a person receives a COVID-19 vaccine might influence how well it protects them from the disease1.
To evaluate the impact of timing on vaccine effectiveness, Guy Hazan at Washington University in Saint Louis, Missouri, and colleagues evaluated a data set of more than 1.5 million people who had received at least one COVID-19 shot.
People who had been vaccinated in the middle of the day — between late morning and early afternoon — had a lower risk of SARS-CoV-2 infection than did those who had received their jab in the evening, according to the analysis. The benefits of being vaccinated during the day were greater for people younger than 20 and older than 50.
The phenomenon might be associated with the body’s circadian rhythm, daily oscillations driven by the day–night cycle. But the exact mechanism responsible for the link between vaccination time and effectiveness is still unclear.
The findings might inform future immunization strategies that would prioritize vaccinating younger and older people between late morning and early afternoon, the authors suggest.
Nature 617, 226 (2023)
doi: https://doi.org/10.1038/d41586-023-01463-6
References
Hazan, G. et al. J. Clin. Invest. https://doi.org/10.1172/JCI167339 (2023).
(Yes, that's it. That's what was behind the paywall).
Thanks for that!
Ask me if you ever want any more.
Thanks for this ExcessAwesomeness
Or it has everything to do with the storage practice at the vaccination site and the alertness of the vaccination staff. Did they not say that each vial has to be shaken 10 times up and down before withdrawing with the syringe?
This MUST only be done if the vials are fresh and have been properly stored since then right up until the needle sucks it up and jabs some poor “unsuspecting” (read “utterly unaware of objective reality”) SUCKER and another one “potentially”😏 bites the dust. The vials must have been rotated and revolved ten times COUNTERCLOCKWISE(this is VITAL!) and THEN clockwise 🔁. Only FRESH NEEDLES and SYRINGES must be used.
I’m going to thank you for your bravery and your sharing spirit!